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Issue 12, 2011
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Bacteria-based biocomputing with Cellular Computing Circuits to sense, decide, signal, and act

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Abstract

Although the term ‘Biocomputing’ may bring to mind biological replacements of silicon processors; this type of application is far in the future. Use of bacteria-based Biocomputing for biosensors and industrial fermentation control, however, is presently attainable by using genetically-engineered bacterial cells that can process signals in a logical operation via one or a few pathways. Here, we refer to these systems as ‘Cellular Computing Circuits’ and focus on their possible future implementations. We also briefly discuss concepts from Synthetic Biology and enzyme-based Biocomputing because they will be important during future development. Our lab has already transformed an idea from enzyme-based Biocomputing into a bacteria-based Boolean logic gate with a digital output signal of direct electric current and we suggest future applications in this perspective. We predict useful functions for Cellular Computing Circuits in the near future.

Graphical abstract: Bacteria-based biocomputing with Cellular Computing Circuits to sense, decide, signal, and act

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Publication details

The article was received on 23 Aug 2011, accepted on 11 Oct 2011 and first published on 31 Oct 2011


Article type: Perspective
DOI: 10.1039/C1EE02455H
Citation: Energy Environ. Sci., 2011,4, 4907-4916
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    Bacteria-based biocomputing with Cellular Computing Circuits to sense, decide, signal, and act

    M. A. TerAvest, Z. Li and L. T. Angenent, Energy Environ. Sci., 2011, 4, 4907
    DOI: 10.1039/C1EE02455H

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