Design of a magnesium-pridinolum complex for polylactide–drug conjugates formation

Tomasz Han; Józef Utko; Lucjan B. Jerzykiewicz; Piotr Sobota

doi:10.1039/C1DT11545F

Design of a magnesium-pridinolum complex for polylactide–drug conjugates formation

Tomasz Han,^a Józef Utko,^a Lucjan B. Jerzykiewicz^a and Piotr Sobota*^a

* Corresponding authors

^a Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, Wroclaw, Poland
E-mail: plas@wchuwr.pl
Fax: +48 (71) 328 23 48
Tel: +48 (71) 375 73 06

Abstract

Polylactide conjugates of the muscle contraction agent Pridinolum (PriOH = 1,1-diphenyl-3-(1-piperidinyl)-1-propanol) were prepared directly by ring-opening polymerization of L-lactide (L-LA) mediated by the pridinolummagnesium complex [Mg(μ,η²-OPri)(η¹-OPri)]₂. The ancillary O,N - bifunctional drug as a ligand stabilizes the magnesium species and initiates L-LA polymerization affording a polymer chain terminated by covalently attached drug molecules to the PLLA through ester linkers to form PriO–PLLA conjugate. Up to 80% of the pridinolum can be released from the conjugate by treatment with deuterated hydrochloric acid DCl at pH = 1.5 for 10 h at 37 °C.

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Publication details

The article was received on 17 Aug 2011, accepted on 07 Oct 2011 and first published on 03 Nov 2011

Article type: Communication

DOI: 10.1039/C1DT11545F

Citation: Dalton Trans., 2011,40, 12660-12662

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Design of a magnesium-pridinolum complex for polylactide–drug conjugates formation

T. Han, J. Utko, L. B. Jerzykiewicz and P. Sobota, Dalton Trans., 2011, 40, 12660
DOI: 10.1039/C1DT11545F
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Design of a magnesium-pridinolum complex for polylactide–drug conjugates formation

Abstract

Supplementary files

Publication details

Design of a magnesium-pridinolum complex for polylactide–drug conjugates formation

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