Jump to main content
Jump to site search

Issue 33, 2011
Previous Article Next Article

A re-investigation of [Fe(L-cysteinate)2(CO)2]2: an example of non-heme CO coordination of possible relevance to CO binding to ion channel receptors

Author affiliations

Abstract

[Fe(L-cysteinate)2(CO)2]2 is a CO releasing molecule which has low cytotoxicity to RAW264.7 macrophages. It provides an example of CO binding using ligands available to ion channels which use CO as a signalling molecule in the absence of heme. Previous work has shown that this compound consists of five isomers and it was proposed that the two isomers with trans-dicarbonyls are dominant. In this work the isomers are re-assigned and shown to be capable of releasing CO, albeit too slowly to act as a signalling receptor. It is shown that by linking the two L-cysteines together to form [Fe(SCH2CH{CO2H}NHCH2)2(CO)2], only one isomer is isolated.

Graphical abstract: A re-investigation of [Fe(l-cysteinate)2(CO)2]2−: an example of non-heme CO coordination of possible relevance to CO binding to ion channel receptors

Back to tab navigation

Supplementary files

Publication details

The article was received on 28 Feb 2011, accepted on 08 Jun 2011 and first published on 15 Jul 2011


Article type: Paper
DOI: 10.1039/C1DT10338E
Citation: Dalton Trans., 2011,40, 8328-8334
  •   Request permissions

    A re-investigation of [Fe(L-cysteinate)2(CO)2]2: an example of non-heme CO coordination of possible relevance to CO binding to ion channel receptors

    L. Hewison, T. R. Johnson, B. E. Mann, A. J. H. M. Meijer, P. Sawle and R. Motterlini, Dalton Trans., 2011, 40, 8328
    DOI: 10.1039/C1DT10338E

Search articles by author

Spotlight

Advertisements