Issue 38, 2011
From the journal:

Dalton Transactions

Cobalaminreduction by dithionite. Evidence for the formation of a six-coordinate cobalamin(ii) complex†

Denis S. Salnikov,ab   Radu Silaghi-Dumitrescu,c   Sergei V. Makarov,*a   Rudi van Eldikb  and  Gerry R. Bossd  

* Corresponding authors

a State University of Chemistry and Technology, Engels str., 7, Ivanovo, Russia
E-mail: makarov@isuct.ru

b Department of Chemistry and Pharmacy, University of Erlangen-Nürnberg, Egerlandstrasse 1, Erlangen, Germany
E-mail: vaneldik@chemie.uni-erlangen.de

c ”Babes-Bolyai” University, Romania
E-mail: rsilaghi@chem.ubbcluj.ro

d Department of Medicine, University of California-San Diego, La Jolla, California, USA
E-mail: gboss@ucsd.edu

Abstract

Evidence for the formation of a unique, six-coordinate cobalamin(II) complex with the anion-radical SO2− during the reduction of aquacobalamin(III) by sodium dithionite, was obtained from spectrophotometric and EPR measurements. The pKa value of the weakly coordinated dimethylbenzimidazole group was found to be 4.8 ± 0.1 at 25 °C.

Graphical abstract: Cobalamin reduction by dithionite. Evidence for the formation of a six-coordinate cobalamin(ii) complex

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Article information

DOI
https://doi.org/10.1039/C1DT10219B
Article type
Paper
Submitted
08 Feb 2011
Accepted
24 Jun 2011
First published
30 Aug 2011

Dalton Trans., 2011,40, 9831-9834

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Cobalamin reduction by dithionite. Evidence for the formation of a six-coordinate cobalamin(II) complex

D. S. Salnikov, R. Silaghi-Dumitrescu, S. V. Makarov, R. van Eldik and G. R. Boss, Dalton Trans., 2011, 40, 9831 DOI: 10.1039/C1DT10219B

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