Jump to main content
Jump to site search

Issue 18, 2011
Previous Article Next Article

A luminescent and mesoporous core-shell structured Gd2O3<img border='0' src='http://www.rsc.org/images/entities/h2_char_2009.gif' alt=' '/>:<img border='0' src='http://www.rsc.org/images/entities/h2_char_2009.gif' alt=' '/>Eu3+@nSiO2@mSiO2 nanocomposite as a drug carrier

Author affiliations

Abstract

In this paper, Gd2O3 : Eu3+ nanospheres have been encapsulated with nonporous silica and further layer of ordered mesoporous silica through a simple sol–gel process. X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), N2adsorption/desorption, photoluminescence (PL) spectra, and kinetic decay were used to characterize the sample. The results indicate that the nanocomposite with general 50 nm shell thickness and 270 nm core size shows typical ordered mesoporous characteristics (2.4 nm) and has spherical morphology with a smooth surface and narrow size distribution. Additionally, the obtained inorganic nanocomposite shows the characteristic emission of Eu3+ (5D07F1–4) even after the loading of drug molecules. The biocompatibility test on L929 fibroblast cells using MTT assay reveals low cytotoxicity of the system. Most importantly, the nanocomposite can be used as an effective drug delivery carrier. A typical anticancer drug, doxorubicin hydrochloride (DOX), was used for drug loading, and the DOX release, cytotoxicity, uptake behavior and therapeutic effects were examined. It was found that DOX is shuttled into the cell by the nanocomposite and released inside cells after endocytosis and that the DOX-loaded nanocomposite exhibited greater cytotoxicity than free DOX. These results indicate that core-shell structured Gd2O3 : Eu3+@nSiO2@mSiO2 nanocomposite has potential for drug loading and delivery into cancer cells to induce cell death.

Graphical abstract: A luminescent and mesoporous core-shell structured Gd2O3<img border='0' src='http://www.rsc.org/images/entities/char_2009.gif' alt=' '/>:<img border='0' src='http://www.rsc.org/images/entities/char_2009.gif' alt=' '/>Eu3+@nSiO2@mSiO2 nanocomposite as a drug carrier

Back to tab navigation

Publication details

The article was received on 29 Jan 2011, accepted on 24 Feb 2011 and first published on 24 Mar 2011


Article type: Paper
DOI: 10.1039/C1DT10162E
Citation: Dalton Trans., 2011,40, 4846-4854
  •   Request permissions

    A luminescent and mesoporous core-shell structured Gd2O3<img border='0' src='http://www.rsc.org/images/entities/h2_char_2009.gif' alt=' '/>:<img border='0' src='http://www.rsc.org/images/entities/h2_char_2009.gif' alt=' '/>Eu3+@nSiO2@mSiO2 nanocomposite as a drug carrier

    Z. Xu, Y. Gao, S. Huang, P. A. Ma, J. Lin and J. Fang, Dalton Trans., 2011, 40, 4846
    DOI: 10.1039/C1DT10162E

Search articles by author

Spotlight

Advertisements