Issue 8, 2011

Metal-mediated aggregation of DNA comprising 2,2′-bipyridine nucleoside, an asymmetrically substituted chiral bidentate ligand

Abstract

The incorporation of an artificial 5-methyl-2,2′-bipyridine nucleoside at the 5′ terminus of an otherwise self-complementary oligonucleotide sequence opens up the opportunity of metal-mediated aggregation of DNA double helices triggered by the addition of the respective metal ions. Interestingly, two-dimensional aggregates (DNA monolayers) are formed in the presence of nickel(II), whereas copper(II) leads to the formation of three-dimensional disc-shaped structures. With iron(II), a coexistence of both types of aggregates had been observed previously. Models are proposed in which these observations are explained based on geometrical considerations. The artificial nucleoside itself represents a rare example for a C1-symmetric chiral derivative of 2,2′-bipyridine, enabling the formation of four isomeric octahedral complexes.

Graphical abstract: Metal-mediated aggregation of DNA comprising 2,2′-bipyridine nucleoside, an asymmetrically substituted chiral bidentate ligand

Supplementary files

Article information

Article type
Paper
Submitted
11 Nov 2010
Accepted
20 Dec 2010
First published
20 Jan 2011

Dalton Trans., 2011,40, 1802-1807

Metal-mediated aggregation of DNA comprising 2,2′-bipyridine nucleoside, an asymmetrically substituted chiral bidentate ligand

N. Megger, L. Welte, F. Zamora and J. Müller, Dalton Trans., 2011, 40, 1802 DOI: 10.1039/C0DT01569E

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