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Issue 12, 2011
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Comparison between α- and β-carbonic anhydrases: can Zn(His)3(H2O) and Zn(His)(Cys)2(H2O) sites lead to equivalent enzymes?

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Abstract

Large models of α- and β-carbonic anhydrases were compared using DFT calculations. They indicate similar acidity of the coordinated water molecule and zinc affinity. This explains their similar mechanism of action, despite the wide difference in their first coordination sphere.

Graphical abstract: Comparison between α- and β-carbonic anhydrases: can Zn(His)3(H2O) and Zn(His)(Cys)2(H2O) sites lead to equivalent enzymes?

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Publication details

The article was received on 22 Oct 2010, accepted on 12 Jan 2011 and first published on 04 Feb 2011


Article type: Communication
DOI: 10.1039/C0DT01454K
Citation: Dalton Trans., 2011,40, 2696-2698
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    Comparison between α- and β-carbonic anhydrases: can Zn(His)3(H2O) and Zn(His)(Cys)2(H2O) sites lead to equivalent enzymes?

    F. Pannetier, G. Ohanessian and G. Frison, Dalton Trans., 2011, 40, 2696
    DOI: 10.1039/C0DT01454K

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