Jump to main content
Jump to site search

Issue 16, 2011
Previous Article Next Article

A set of highly water-soluble tetraethyleneglycol-substituted Zn(II) phthalocyanines: synthesis, photochemical and photophysical properties, interaction with plasma proteins and in vitro phototoxicity

Author affiliations

Abstract

Three Zn(II) phthalocyanines substituted by hydroxyl-terminated tetraethylene glycol chains have been synthesized. In order to evaluate the potential of these highly water-soluble phthalocyanines as type II-photosensitisers for photodynamic therapy, their structure–activity relationship was assessed by determining relevant photophysical and photochemical properties, such as their aggregation behaviour in aqueous buffers, their fluorescence properties and their efficiency with regard to the generation of singlet oxygen. In addition, evidence for a negligible interaction with plasma proteins in undiluted human plasma was obtained using a recently developed bioanalytical method and compared with the fluorescence quenching approach. These results combined with in vitro data regarding the phototoxicity of these phthalocyanines against HT-29 cancer cells provide evidence for the relevance of the non-peripherally substituted derivative for further in vivo investigations.

Graphical abstract: A set of highly water-soluble tetraethyleneglycol-substituted Zn(ii) phthalocyanines: synthesis, photochemical and photophysical properties, interaction with plasma proteins and in vitro phototoxicity

Back to tab navigation

Supplementary files

Publication details

The article was received on 18 Sep 2010, accepted on 04 Nov 2010 and first published on 14 Dec 2010


Article type: Paper
DOI: 10.1039/C0DT01260B
Citation: Dalton Trans., 2011,40, 4067-4079
  •   Request permissions

    A set of highly water-soluble tetraethyleneglycol-substituted Zn(II) phthalocyanines: synthesis, photochemical and photophysical properties, interaction with plasma proteins and in vitro phototoxicity

    S. Tuncel, F. Dumoulin, J. Gailer, M. Sooriyaarachchi, D. Atilla, M. Durmuş, D. Bouchu, H. Savoie, R. W. Boyle and V. Ahsen, Dalton Trans., 2011, 40, 4067
    DOI: 10.1039/C0DT01260B

Search articles by author

Spotlight

Advertisements