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Issue 2, 2011
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The preparation and characterization of trans-platinum(IV) complexes with unusually high cytotoxicity

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Abstract

The physical and biological properties have been determined for three Pt(IV) complexes with transamine ligands: trans,trans,trans-[PtCl2(OH)2(dimethylamine)(isopropylamine)] (1IV), trans,trans,trans-[PtCl2(OH)2(dimethylamine)(methylamine)] (2IV) and trans,trans,trans-[PtCl2(OH)2(isopropylamine)(methylamine)] (3IV). The crystal structures of 2IV and 3IV reveal substantial strain resulting from repulsion between the amine ligands and the chlorido and hydroxido ligands. All three complexes have reduction potentials in the range −666 to −770 mV, values usually associated with high resistance to reduction and low cytotoxicity. However, the complexes all demonstrate surprisingly high cytotoxicity with values and trends that closely follow those seen for the Pt(II) congeners of these complexes. These results are consistent with more rapid reduction of the Pt(IV) complexes than would be expected based on the reduction potentials, perhaps associated with the trans arrangement of the chlorido ligands.

Graphical abstract: The preparation and characterization of trans-platinum(iv) complexes with unusually high cytotoxicity

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Publication details

The article was received on 28 May 2010, accepted on 27 Jul 2010 and first published on 08 Oct 2010


Article type: Paper
DOI: 10.1039/C0DT00565G
Citation: Dalton Trans., 2011,40, 344-347
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    The preparation and characterization of trans-platinum(IV) complexes with unusually high cytotoxicity

    L. Cubo, T. W. Hambley, P. J. Sanz Miguel, A. Carnero, C. Navarro-Ranninger and A. G. Quiroga, Dalton Trans., 2011, 40, 344
    DOI: 10.1039/C0DT00565G

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