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Issue 8, 2011
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Chemical genetics

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Abstract

Chemical genetics can be defined as the study of biological systems using small molecule tools. Cell permeable and selective small molecules modulate gene product function rapidly, reversibly and can be administered conditionally in either a cellular or organismal context. The small molecule approach provides exacting temporal and quantitative control and is therefore an extremely powerful tool for dissecting biological processes. This tutorial review has been written to introduce the subject to a broad audience and highlights recent developments within the field in four key areas of biology: modulating protein–protein interactions, malaria research, hepatitis C virus research, and disrupting RNA interference pathways.

Graphical abstract: Chemical genetics

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Publication details

The article was received on 24 Feb 2011 and first published on 12 May 2011


Article type: Tutorial Review
DOI: 10.1039/C1CS15053G
Citation: Chem. Soc. Rev., 2011,40, 4332-4345
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    Chemical genetics

    C. J. O' Connor, L. Laraia and D. R. Spring, Chem. Soc. Rev., 2011, 40, 4332
    DOI: 10.1039/C1CS15053G

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