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Issue 12, 2011
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Nucleobase modification as redox DNA labelling for electrochemical detection

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Abstract

Basic aspects of DNA electrochemistry with a strong focus on the use of modified nucleobases as redox probes for electrochemical bioanalysis are reviewed. Intrinsic electrochemical properties of nucleobases in combination with artificial redox-active nucleobase modifications are frequently applied in this field. Synthetic approaches (both chemical and enzymatic) to base-modified nucleic acids are briefly summarized and their applications in redox labelling are discussed. Finally, analytical applications including DNA hybridization, primer extension, PCR, SNP typing, DNA damage and DNA–protein interaction analysis are presented (critical review, 91 references).

Graphical abstract: Nucleobase modification as redox DNA labelling for electrochemical detection

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Publication details

The article was received on 23 Feb 2011 and first published on 31 May 2011


Article type: Critical Review
DOI: 10.1039/C1CS15049A
Citation: Chem. Soc. Rev., 2011,40, 5802-5814
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    Nucleobase modification as redox DNA labelling for electrochemical detection

    M. Hocek and M. Fojta, Chem. Soc. Rev., 2011, 40, 5802
    DOI: 10.1039/C1CS15049A

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