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Issue 4, 2011
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Guiding principles for site selective and stereoselective intermolecular C–H functionalization by donor/acceptor rhodium carbenes

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Abstract

This tutorial review presents a description of the controlling elements of intermolecular C–H functionalization by means of C–H insertion by donor/acceptor rhodium carbenes. These rhodium carbenes, readily derived from the combination of diazo compounds with dirhodium(II) catalysts, are sufficiently reactive to undergo a wide range of C–H insertions. They are also capable of highly selective reactions, controlled by a combination of steric and electronic factors. An overview of the structural factors that influence site selectivity will be given, followed by a description of the exceptional diastereo- and enantioselectivity that can be achieved. Several examples will be shown of how this methodology can be applied to streamline the synthesis of natural products and pharmaceutical targets.

Graphical abstract: Guiding principles for site selective and stereoselective intermolecular C–H functionalization by donor/acceptor rhodium carbenes

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Publication details

The article was received on 17 Dec 2010 and first published on 01 Mar 2011


Article type: Tutorial Review
DOI: 10.1039/C0CS00217H
Citation: Chem. Soc. Rev., 2011,40, 1857-1869
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    Guiding principles for site selective and stereoselective intermolecular C–H functionalization by donor/acceptor rhodium carbenes

    H. M. L. Davies and D. Morton, Chem. Soc. Rev., 2011, 40, 1857
    DOI: 10.1039/C0CS00217H

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