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Issue 7, 2011
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Diversity-driven chemical probe development for biomolecules: beyond hypothesis-driven approach

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Abstract

Bioprobes are indispensable tools for biological study and clinical diagnosis. A conventional strategy for probe development is hypothesis-driven approach based on known molecular mechanisms of recognition for individual analytes. However, even the most sophisticated rational design does not always guarantee the applicability of probes in complex biological systems, therefore the efficiency and scope of probe development has been intrinsically limited. Diversity-driven approach is a rapidly emerging alternative and has been employed for the development of new probes even in the absence of the knowledge about target recognition mechanism. This tutorial review summarizes the recent advances in probe development along with conceptual advantages and perspectives of the diversity-driven approach.

Graphical abstract: Diversity-driven chemical probe development for biomolecules: beyond hypothesis-driven approach

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Publication details

The article was received on 06 Nov 2010 and first published on 27 Apr 2011


Article type: Tutorial Review
DOI: 10.1039/C0CS00172D
Citation: Chem. Soc. Rev., 2011,40, 3613-3626
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    Diversity-driven chemical probe development for biomolecules: beyond hypothesis-driven approach

    N. Kang, H. Ha, S. Yun, Y. H. Yu and Y. Chang, Chem. Soc. Rev., 2011, 40, 3613
    DOI: 10.1039/C0CS00172D

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