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Issue 5, 2011
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Immobilization of bio-macromolecules on self-assembled monolayers: methods and sensor applications

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Abstract

Attachment of biomolecules on gold, silicon or glass surfaces has direct implications for the development of novel biosensors in the context of nanoscale detection of pathogens and other metabolites related to issues of human health. In this critical review, we have highlighted the current developments in various techniques of immobilization of biomolecules, specifically biological macromolecules on surfaces through the modification of a functional self-assembled monolayer. The utility of such immobilized biomolecules in the area of biosensing in nanoscale has been surveyed. Merits and demerits of some of the methods with reference to sensitivity of detection and practical use have been discussed (221 references).

Graphical abstract: Immobilization of bio-macromolecules on self-assembled monolayers: methods and sensor applications

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Publication details

The article was received on 27 Jul 2010 and first published on 24 Jan 2011


Article type: Critical Review
DOI: 10.1039/C0CS00056F
Citation: Chem. Soc. Rev., 2011,40, 2567-2592
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    Immobilization of bio-macromolecules on self-assembled monolayers: methods and sensor applications

    D. Samanta and A. Sarkar, Chem. Soc. Rev., 2011, 40, 2567
    DOI: 10.1039/C0CS00056F

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