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Issue 30, 2011
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Para-hydrogen induced polarization of amino acids, peptides and deuteriumhydrogen gas

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Abstract

Signal Amplification by Reversible-Exchange (SABRE) is a method of hyperpolarizing substrates by polarization transfer from para-hydrogen without hydrogenation. Here, we demonstrate that this method can be applied to hyperpolarize small amounts of all proteinogenic amino acids and some chosen peptides down to the nanomole regime and can be detected in a single scan in low-magnetic fields down to 0.25 mT (10 kHz proton frequency). An outstanding feature is that depending on the chemical state of the used catalyst and the investigated amino acid or peptide, hyperpolarized hydrogendeuterium gas is formed, which was detected with 1H and 2H NMR spectroscopy at low magnetic fields of B0 = 3.9 mT (166 kHz proton frequency) and 3.2 mT (20 kHz deuterium frequency).

Graphical abstract: Para-hydrogen induced polarization of amino acids, peptides and deuterium–hydrogen gas

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Publication details

The article was received on 31 Mar 2011, accepted on 13 Jun 2011 and first published on 01 Jul 2011


Article type: Paper
DOI: 10.1039/C1CP20992B
Citation: Phys. Chem. Chem. Phys., 2011,13, 13759-13764
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    Para-hydrogen induced polarization of amino acids, peptides and deuteriumhydrogen gas

    S. Glöggler, R. Müller, J. Colell, M. Emondts, M. Dabrowski, B. Blümich and S. Appelt, Phys. Chem. Chem. Phys., 2011, 13, 13759
    DOI: 10.1039/C1CP20992B

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