Issue 19, 2011

Top-down and bottom-up approaches in production of aqueous nanocolloids of low solubility drug paclitaxel

Abstract

Nano-encapsulation of a poorly soluble anticancer drug was demonstrated with a sonication assisted layer-by-layer polyelectrolyte coating (SLbL). We changed the strategy of LbL-encapsulation from making microcapsules with many layers in the walls for encasing highly soluble materials to using a very thin polycation/polyanion coating on low solubility nanoparticles to provide them with good colloidal stability. SLbL encapsulation of paclitaxel resulted in stable 100–200 nm diameter colloids with a high electrical surface ξ-potential (of −45 mV) and drug content in the nanoparticles of 90 wt%. In the top-down approach, nanocolloids were prepared by rupturing a powder of paclitaxel using ultrasonication and simultaneous sequential adsorption of oppositely charged biocompatible polyelectrolytes. In the bottom-up approach paclitaxel was dissolved in organic solvent (ethanol or acetone), and drug nucleation was initiated by the addition of aqueous polyelectrolyte assisted by ultrasonication. Paclitaxel release rates from such nanocapsules were controlled by assembling multilayer shells with variable thicknesses and were in the range of 10–20 h.

Graphical abstract: Top-down and bottom-up approaches in production of aqueous nanocolloids of low solubility drug paclitaxel

Article information

Article type
Paper
Submitted
16 Nov 2010
Accepted
25 Feb 2011
First published
25 Mar 2011

Phys. Chem. Chem. Phys., 2011,13, 9014-9019

Top-down and bottom-up approaches in production of aqueous nanocolloids of low solubility drug paclitaxel

P. Pattekari, Z. Zheng, X. Zhang, T. Levchenko, V. Torchilin and Y. Lvov, Phys. Chem. Chem. Phys., 2011, 13, 9014 DOI: 10.1039/C0CP02549F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements