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Issue 6, 2011
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Highly soluble olanzapinium maleate crystalline salts

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Abstract

Olanzapinium monomaleate and dimaleate salts (OLNH+ MA 1 : 1 and OLN2H+ 2MA 1 : 2) of crystalline and amorphous states were prepared. The crystalline salts exhibit significantly higher solubility (225–550 times) compared to the almost insoluble free base drug Olanzapine (43 mg L−1). The faster dissolution rate of the 1 : 2 salt compared to 1 : 1 is explained by their crystal structure analysis.

Graphical abstract: Highly soluble olanzapinium maleate crystalline salts

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Publication details

The article was received on 28 Oct 2010, accepted on 13 Dec 2010 and first published on 07 Jan 2011


Article type: Communication
DOI: 10.1039/C0CE00787K
Citation: CrystEngComm, 2011,13, 1759-1764
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    Highly soluble olanzapinium maleate crystalline salts

    R. Thakuria and A. Nangia, CrystEngComm, 2011, 13, 1759
    DOI: 10.1039/C0CE00787K

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