Issue 3, 2011
From the journal:

CrystEngComm

Characterization, physicochemical and photo-stability of a co-crystal involving an antibioticdrug, nitrofurantoin, and 4-hydroxybenzoic acid†

Venu R. Vangala,*a   Pui Shan Chowa  and  Reginald B. H. Tan*ab  

* Corresponding authors

a Crystallisation and Particle Science, Institute of Chemical and Engineering Sciences, A*STAR (Agency for Science Technology and Research), 1, Pesek Road, Jurong Island, Singapore
E-mail: venugopal_vangala@ices.a-star.edu.sg
Fax: +65 6316 6183
Tel: +65 6796 3862

b Department of Chemical & Biomolecular Engineering, National University of Singapore, 10 Kent Ridge Crescent, Singapore
E-mail: reginald_tan@ices.a-star.edu.sg

Abstract

Pharmaceutical co-crystallizing ability of an antibiotic agent, nitrofurantoin, is screened with three isomeric monohydroxybenzoic acids. 1 : 1 co-crystal of nitrofurantoin-4-hydroxybenzoic acid has been prepared and structurally characterized. Further, the co-crystal displays superior physicochemical and photo-stability compared to nitrofurantoin.

Graphical abstract: Characterization, physicochemical and photo-stability of a co-crystal involving an antibiotic drug, nitrofurantoin, and 4-hydroxybenzoic acid

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Article information

DOI
https://doi.org/10.1039/C0CE00772B
Article type
Communication
Submitted
26 Oct 2010
Accepted
22 Nov 2010
First published
08 Dec 2010

CrystEngComm, 2011,13, 759-762

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Characterization, physicochemical and photo-stability of a co-crystal involving an antibiotic drug, nitrofurantoin, and 4-hydroxybenzoic acid

V. R. Vangala, P. S. Chow and R. B. H. Tan, CrystEngComm, 2011, 13, 759 DOI: 10.1039/C0CE00772B

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