Issue 14, 2012
From the journal:

Chemical Communications

Site-specific incorporation of diamondoids on DNA using click chemistry†

Jason B. Crumptona  and  Webster L. Santos*a  

* Corresponding authors

a Department of Chemistry, Virginia Tech, Blacksburg, Virginia 24061, USA
E-mail: santosw@vt.edu
Fax: +1 540 231 3255
Tel: +1 540 231 5041

Abstract

A simple and robust solid phase synthetic method for the ligation of diamondoids on the phosphate backbone of DNA with “click” chemistry using [Cu(CH3CN)4]PF6 without a stabilizing ligand is reported. It was found that as the size of dimondoid increased, a corresponding increase in melting temperature was observed.

Graphical abstract: Site-specific incorporation of diamondoids on DNA using click chemistry

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Article information

DOI
https://doi.org/10.1039/C2CC16860J
Article type
Communication
Submitted
04 Nov 2011
Accepted
20 Dec 2011
First published
20 Dec 2011

Chem. Commun., 2012,48, 2018-2020

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Site-specific incorporation of diamondoids on DNA using click chemistry

J. B. Crumpton and W. L. Santos, Chem. Commun., 2012, 48, 2018 DOI: 10.1039/C2CC16860J

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