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Issue 48, 2011
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A concise route to the macrocyclic core of the rakicidins

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Abstract

An efficient synthesis of the macrolactone core of the rakicidins is described. The rakicidins are cytotoxic lipopeptides with interesting cancer cell selectivities including HIF-1-independent hypoxia-selective cytotoxicity and anti-invasive activity. Access to the core may now allow establishment of preliminary SAR and exploration of routes to several members of rakicidins.

Graphical abstract: A concise route to the macrocyclic core of the rakicidins

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Publication details

The article was received on 20 Sep 2011, accepted on 18 Oct 2011 and first published on 02 Nov 2011


Article type: Communication
DOI: 10.1039/C1CC15829E
Citation: Chem. Commun., 2011,47, 12837-12839
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    A concise route to the macrocyclic core of the rakicidins

    T. B. Poulsen, Chem. Commun., 2011, 47, 12837
    DOI: 10.1039/C1CC15829E

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