Issue 44, 2011
From the journal:

Chemical Communications

Thermosensitive dendrimer formulation for drug delivery at physiologically relevant temperatures†

Annie Castonguay,a   Eleanor Wilson,a   Noura Al-Hajaj,b   Laurène Petitjean,a   Julie Paoletti,a   Dusica Maysinger*b  and  Ashok Kakkar*a  

* Corresponding authors

a Department of Chemistry, McGill University, 801 Sherbrooke St. West, Montreal, Quebec, Canada
E-mail: ashok.kakkar@mcgill.ca
Fax: +514-398-3797
Tel: 514-398-6912

b Department of Pharmacology and Therapeutics, McGill University, 3655 Promenade Sir-William-Osler, Montreal, Quebec, Canada
E-mail: Dusica.maysinger@mcgill.ca
Fax: +514-398-6690
Tel: +514-398-1264

Abstract

A simple and versatile dendrimer based platform to deliver therapeutic agents at temperatures within the physiological range, is reported. Lipoic acid conjugated at the periphery of the thermosensitive dendrimer formulations undergoes slow and sustained release at 37–42 °C, and rescues the cells from oxidative stress and a pro-inflammatory endotoxic agent.

Graphical abstract: Thermosensitive dendrimer formulation for drug delivery at physiologically relevant temperatures

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Article information

DOI
https://doi.org/10.1039/C1CC15354D
Article type
Communication
Submitted
28 Aug 2011
Accepted
23 Sep 2011
First published
12 Oct 2011

Chem. Commun., 2011,47, 12146-12148

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Thermosensitive dendrimer formulation for drug delivery at physiologically relevant temperatures

A. Castonguay, E. Wilson, N. Al-Hajaj, L. Petitjean, J. Paoletti, D. Maysinger and A. Kakkar, Chem. Commun., 2011, 47, 12146 DOI: 10.1039/C1CC15354D

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