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Issue 42, 2011
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Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of N-substituted benzenesulfonamides to human isoform II

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Abstract

N-substituted benzenesulfonamides, incorporating the N-amino-, N-hydroxy- and N-methoxy-moieties at the sulfonamide zinc binding group, have been investigated as CAIs by means of inhibition and structural studies, unraveling interesting aspects related to their inhibition mechanism.

Graphical abstract: Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of N-substituted benzenesulfonamides to human isoform II

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Publication details

The article was received on 26 Jul 2011, accepted on 08 Sep 2011 and first published on 26 Sep 2011


Article type: Communication
DOI: 10.1039/C1CC14575D
Citation: Chem. Commun., 2011,47, 11636-11638
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    Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of N-substituted benzenesulfonamides to human isoform II

    A. Di Fiore, A. Maresca, V. Alterio, C. T. Supuran and G. De Simone, Chem. Commun., 2011, 47, 11636
    DOI: 10.1039/C1CC14575D

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