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Issue 34, 2011
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Non-hemolytic α-AApeptides as antimicrobial peptidomimetics

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Abstract

We report a new class of peptide mimetics, α-AApeptides, that display broad-spectrum activity against both Gram-negative and Gram-positive bacteria and fungi. With non-hemolytic activity, resistance to protease hydrolysis, and easy sequence programmability, α-AApeptides may emerge as a novel class of antibiotics.

Graphical abstract: Non-hemolytic α-AApeptides as antimicrobial peptidomimetics

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Publication details

The article was received on 20 Jun 2011, accepted on 06 Jul 2011 and first published on 21 Jul 2011


Article type: Communication
DOI: 10.1039/C1CC13684D
Citation: Chem. Commun., 2011,47, 9729-9731
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    Non-hemolytic α-AApeptides as antimicrobial peptidomimetics

    S. Padhee, Y. Hu, Y. Niu, G. Bai, H. Wu, F. Costanza, L. West, L. Harrington, L. N. Shaw, C. Cao and J. Cai, Chem. Commun., 2011, 47, 9729
    DOI: 10.1039/C1CC13684D

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