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Issue 37, 2011
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Progress toward developing a carbohydrate-conjugate vaccine against Clostridium difficile ribotype 027: synthesis of the cell-surface polysaccharide PS-I repeating unit

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Abstract

Clostridium difficile strain ribotype 027 is a hypervirulent pathogen that is responsible for recent, severe outbreaks of serious nosocomial infections. As a foundation for the development of a preventative carbohydrate-based vaccine, we have synthesized a pentasaccharide cell wall repeating unit from PS-I unique to this strain, by the linear assembly of four monosaccharide building blocks.

Graphical abstract: Progress toward developing a carbohydrate-conjugate vaccine against Clostridium difficile ribotype 027: synthesis of the cell-surface polysaccharide PS-I repeating unit

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Publication details

The article was received on 17 Jun 2011, accepted on 21 Jul 2011 and first published on 18 Aug 2011


Article type: Communication
DOI: 10.1039/C1CC13614C
Citation: Chem. Commun., 2011,47, 10260-10262
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    Progress toward developing a carbohydrate-conjugate vaccine against Clostridium difficile ribotype 027: synthesis of the cell-surface polysaccharide PS-I repeating unit

    C. E. Martin, M. W. Weishaupt and P. H. Seeberger, Chem. Commun., 2011, 47, 10260
    DOI: 10.1039/C1CC13614C

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