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Issue 34, 2011
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Highly efficient construction of spirocyclic chromanone–pyrrolidinesviaCu(I)/TF–BiphamPhos-catalyzed asymmetric 1,3-dipolar cycloaddition

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Abstract

A facile synthesis of highly functional spiro-[4-chromanone-3,3′-pyrrolidine] bearing one unique spiro quarternary and three tertiary stereogenic centers is developed in excellent stereoselectivity for the first time.

Graphical abstract: Highly efficient construction of spirocyclic chromanone–pyrrolidinesviaCu(i)/TF–BiphamPhos-catalyzed asymmetric 1,3-dipolar cycloaddition

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Publication details

The article was received on 15 Jun 2011, accepted on 15 Jul 2011 and first published on 29 Jul 2011


Article type: Communication
DOI: 10.1039/C1CC13554F
Citation: Chem. Commun., 2011,47, 9600-9602
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    Highly efficient construction of spirocyclic chromanone–pyrrolidinesviaCu(I)/TF–BiphamPhos-catalyzed asymmetric 1,3-dipolar cycloaddition

    T. Liu, Z. He and C. Wang, Chem. Commun., 2011, 47, 9600
    DOI: 10.1039/C1CC13554F

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