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Issue 35, 2011
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Dynamic combinatorial development of a neutral synthetic receptor that binds sulfate with nanomolar affinity in aqueous solution

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Abstract

Using dynamic combinatorial disulfide chemistry we have developed a new generation of neutral synthetic receptors for anions, based on a macrobicyclic peptide structure. These receptors show an exceptional affinity and selectivity for sulfate ions in aqueous solution [log Ka = 8.67 in 41 mol% (67 volume%) acetonitrile in water]. The high affinity depends on a delicate balance between rigidity and flexibility in the structure of the receptor.

Graphical abstract: Dynamic combinatorial development of a neutral synthetic receptor that binds sulfate with nanomolar affinity in aqueous solution

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Publication details

The article was received on 10 Jun 2011, accepted on 12 Jul 2011 and first published on 02 Aug 2011


Article type: Communication
DOI: 10.1039/C1CC13451E
Citation: Chem. Commun., 2011,47, 9798-9800
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    Dynamic combinatorial development of a neutral synthetic receptor that binds sulfate with nanomolar affinity in aqueous solution

    Z. Rodriguez-Docampo, E. Eugenieva-Ilieva, C. Reyheller, A. M. Belenguer, S. Kubik and S. Otto, Chem. Commun., 2011, 47, 9798
    DOI: 10.1039/C1CC13451E

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