Jump to main content
Jump to site search

Issue 39, 2011
Previous Article Next Article

A general synthesis of dirhodium metallopeptides as MDM2 ligands

Author affiliations

Abstract

A synthesis of multifunctional dirhodium metallopeptide ligands for MDM2 is presented. An orthogonal protection scheme of palladium-catalyzed de-allylation on a metallopeptide substrate allows specific dirhodium incorporation in a complex peptide. Sequence effects on MDM2 binding are discussed.

Graphical abstract: A general synthesis of dirhodium metallopeptides as MDM2 ligands

Back to tab navigation

Supplementary files

Publication details

The article was received on 29 May 2011, accepted on 23 Aug 2011 and first published on 12 Sep 2011


Article type: Communication
DOI: 10.1039/C1CC13169A
Citation: Chem. Commun., 2011,47, 10927-10929
  •   Request permissions

    A general synthesis of dirhodium metallopeptides as MDM2 ligands

    A. N. Zaykov and Z. T. Ball, Chem. Commun., 2011, 47, 10927
    DOI: 10.1039/C1CC13169A

Search articles by author

Spotlight

Advertisements