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Issue 31, 2011
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Bromopyridazinedione-mediated protein and peptide bioconjugation

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Abstract

Bromopyridazinedione-mediated bioconjugation to a cysteine containing protein and a disulfide containing peptide is described. The conjugates are cleavable in an excess of thiol, including cytoplasmically-relevant concentrations of glutathione, and show a high level of hydrolytic stability. The constructs have the potential for four points of chemical attachment.

Graphical abstract: Bromopyridazinedione-mediated protein and peptide bioconjugation

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Publication details

The article was received on 12 May 2011, accepted on 20 Jun 2011 and first published on 07 Jul 2011


Article type: Communication
DOI: 10.1039/C1CC12807H
Citation: Chem. Commun., 2011,47, 8781-8783
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    Bromopyridazinedione-mediated protein and peptide bioconjugation

    V. Chudasama, M. E. B. Smith, F. F. Schumacher, D. Papaioannou, G. Waksman, J. R. Baker and S. Caddick, Chem. Commun., 2011, 47, 8781
    DOI: 10.1039/C1CC12807H

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