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Issue 27, 2011
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Au-catalyzed synthesis of 2-alkylindoles from N-arylhydroxylamines and terminal alkynes

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Abstract

The first gold-catalyzed addition of N-arylhydroxylamines to aliphatic terminal alkynes is developed to access O-alkenyl-N-arylhydroxylamines, which undergo facile in situ sequential 3,3-rearrangements and cyclodehydrations to afford 2-alkylindoles with regiospecificity and under exceptionally mild reaction conditions.

Graphical abstract: Au-catalyzed synthesis of 2-alkylindoles from N-arylhydroxylamines and terminal alkynes

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Publication details

The article was received on 17 Apr 2011, accepted on 09 May 2011 and first published on 03 Jun 2011


Article type: Communication
DOI: 10.1039/C1CC12212F
Citation: Chem. Commun., 2011,47, 7815-7817
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    Au-catalyzed synthesis of 2-alkylindoles from N-arylhydroxylamines and terminal alkynes

    Y. Wang, L. Ye and L. Zhang, Chem. Commun., 2011, 47, 7815
    DOI: 10.1039/C1CC12212F

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