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Issue 37, 2011
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Using boronolectin in MALDI-MS imaging for the histological analysis of cancer tissue expressing the sialyl Lewis X antigen

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Abstract

Certain carbohydrate-based biomarkers are known to correlate with cancer formation and progression. By targeting sialyl Lewis X, we have developed the first boronolectin–MS tag conjugate, which allows for MALDI-based imaging of cancer based on its cell surface carbohydrate.

Graphical abstract: Using boronolectin in MALDI-MS imaging for the histological analysis of cancer tissue expressing the sialyl Lewis X antigen

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Publication details

The article was received on 30 Mar 2011, accepted on 04 Aug 2011 and first published on 19 Aug 2011


Article type: Communication
DOI: 10.1039/C1CC11814E
Citation: Chem. Commun., 2011,47, 10338-10340
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    Using boronolectin in MALDI-MS imaging for the histological analysis of cancer tissue expressing the sialyl Lewis X antigen

    C. Dai, L. H. Cazares, L. Wang, Y. Chu, S. L. Wang, D. A. Troyer, O. J. Semmes, R. R. Drake and B. Wang, Chem. Commun., 2011, 47, 10338
    DOI: 10.1039/C1CC11814E

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