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Issue 26, 2011
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A tumor mRNA-dependent gold nanoparticle–molecular beacon carrier for controlled drug release and intracellular imaging

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Abstract

We demonstrate a tumor mRNA-dependent drug carrier for controlled release of doxorubicin (Dox) and intracellular imaging based on gold nanoparticle–molecular beacon. Fluorescent Dox is released effectively and induces apoptosis in breast cancer cells but not in normal cells. Significantly, the release of Dox is correlated positively with the quantities of tumor mRNA, which is according to various stages of tumor progression, and so can decrease effectively side effects of Dox.

Graphical abstract: A tumor mRNA-dependent gold nanoparticle–molecular beacon carrier for controlled drug release and intracellular imaging

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Publication details

The article was received on 15 Mar 2011, accepted on 26 Apr 2011 and first published on 17 May 2011


Article type: Communication
DOI: 10.1039/C1CC11490E
Citation: Chem. Commun., 2011,47, 7458-7460
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    A tumor mRNA-dependent gold nanoparticle–molecular beacon carrier for controlled drug release and intracellular imaging

    G. Qiao, L. Zhuo, Y. Gao, L. Yu, N. Li and B. Tang, Chem. Commun., 2011, 47, 7458
    DOI: 10.1039/C1CC11490E

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