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Issue 20, 2011
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Fluorescent trimethyl-substituted naphthyridine as a ligand for C–C mismatch detection in CCG trinucleotide repeats

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Abstract

We report on the selective binding of 2-amino-5,6,7-trimethyl-1,8-naphthyridine (ATMND) to C–C mismatch present in the hairpin structures of (CCG)n trinucleotide repeats that are associated with neurological diseases; this binding is accompanied by significant fluorescence quenching of ATMND.

Graphical abstract: Fluorescent trimethyl-substituted naphthyridine as a ligand for C–C mismatch detection in CCG trinucleotide repeats

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Publication details

The article was received on 09 Mar 2011, accepted on 29 Mar 2011 and first published on 14 Apr 2011


Article type: Communication
DOI: 10.1039/C1CC11370D
Citation: Chem. Commun., 2011,47, 5885-5887
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    Fluorescent trimethyl-substituted naphthyridine as a ligand for C–C mismatch detection in CCG trinucleotide repeats

    Y. Sato, A. Honjo, D. Ishikawa, S. Nishizawa and N. Teramae, Chem. Commun., 2011, 47, 5885
    DOI: 10.1039/C1CC11370D

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