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Issue 26, 2011
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Synthesis of a new fluorescent small molecule probe and its use for in vivolipid imaging

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Abstract

A new small molecule probe for in vivolipid imaging, LipidGreen (compound 5), was developed. LipidGreen stained lipid droplets in 3T3L1 cell lines and fat deposits in zebrafish without apparent toxicity up to 100 μM. The utility of LipidGreen as a drug screening platform for fat regulation was also demonstrated in live zebrafish.

Graphical abstract: Synthesis of a new fluorescent small molecule probe and its use for in vivolipid imaging

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Publication details

The article was received on 03 Mar 2011, accepted on 12 Apr 2011 and first published on 09 May 2011


Article type: Communication
DOI: 10.1039/C1CC11253H
Citation: Chem. Commun., 2011,47, 7500-7502
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    Synthesis of a new fluorescent small molecule probe and its use for in vivolipid imaging

    J. H. Lee, J. So, J. H. Jeon, E. B. Choi, Y. Lee, Y. Chang, C. Kim, M. A. Bae and J. H. Ahn, Chem. Commun., 2011, 47, 7500
    DOI: 10.1039/C1CC11253H

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