Jump to main content
Jump to site search

Issue 38, 2011
Previous Article Next Article

Brief, efficient and highly diastereoselective synthesis of (±)-pumiliotoxin C based on the generation of an octahydroquinoline precursor via a four-component reaction

Author affiliations

Abstract

A short and highly diastereoselective synthesis of the amphibian alkaloid pumiliotoxin C is described, based on the preparation of an octahydroquinoline derivative through a four-component reaction. The route proceeds in 66% overall yield from 1,3-cyclohexanedione and includes two hydrogenation steps, whose stereochemical outcome was controlled vianitrogen acylation.

Graphical abstract: Brief, efficient and highly diastereoselective synthesis of (±)-pumiliotoxin C based on the generation of an octahydroquinoline precursor via a four-component reaction

Back to tab navigation

Supplementary files

Publication details

The article was received on 02 Mar 2011, accepted on 18 Apr 2011 and first published on 06 May 2011


Article type: Communication
DOI: 10.1039/C1CC11246E
Citation: Chem. Commun., 2011,47, 10554-10556
  •   Request permissions

    Brief, efficient and highly diastereoselective synthesis of (±)-pumiliotoxin C based on the generation of an octahydroquinoline precursor via a four-component reaction

    S. Maiti and J. C. Menéndez, Chem. Commun., 2011, 47, 10554
    DOI: 10.1039/C1CC11246E

Search articles by author

Spotlight

Advertisements