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Issue 21, 2011
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Modular ‘click’ sensors for zinc and their application in vivo

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Abstract

Although the central role that zinc plays in many biological processes and important disease states is now well-established, there remains a pressing need to develop an absolute understanding of the underlying biology of zinc trafficking in terms of its dynamic and quantitative processing in specific organelles. Here we describe the modular synthesis of zinc sensors using a ‘click’ approach and demonstrate the applicability of our new sensors in vivo using a zebrafish model.

Graphical abstract: Modular ‘click’ sensors for zinc and their application in vivo

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Publication details

The article was received on 28 Feb 2011, accepted on 31 Mar 2011 and first published on 28 Apr 2011


Article type: Communication
DOI: 10.1039/C1CC11213A
Citation: Chem. Commun., 2011,47, 6036-6038
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    Modular ‘click’ sensors for zinc and their application in vivo

    K. Jobe, C. H. Brennan, M. Motevalli, S. M. Goldup and M. Watkinson, Chem. Commun., 2011, 47, 6036
    DOI: 10.1039/C1CC11213A

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