Issue 17, 2011
From the journal:

Chemical Communications

X-Ray diffraction analyses of the natural isoquinoline alkaloids Berberine and Sanguinarine complexed with double helix DNA d(CGTACG)†

Marta Ferraroni,a   Carla Bazzicalupi,*a   Anna Rita Biliab  and  Paola Gratteri*bc  

* Corresponding authors

a Department of Chemistry “Ugo Schiff”, University of Firenze, Via della Lastruccia 3-13, I-50019 Sesto Fiorentino, Firenze, Italy
E-mail: carla.bazzicalupi@unifi.it
Fax: +39 0554573385
Tel: +39 0554573286

b Department of Pharmaceutical Sciences, University of Firenze, Via Ugo Schiff 6, I-50019 Sesto Fiorentino, Firenze, Italy

c Laboratory of Molecular Modeling Cheminformatics & QSAR, Department of Pharmaceutical Sciences, University of Firenze, Via Ugo Schiff 6, I-50019 Sesto Fiorentino, Firenze, Italy
E-mail: paola.gratteri@unifi.it
Fax: +39 0554573380
Tel: +39 0554573702

Abstract

The first crystal structures of Berberine and Sanguinarine intercalated with a d(CGTACG)2 DNA sequence were obtained by X-ray diffraction analysis at 2.3 Å resolution. Both drugs join the end of two “two-molecules” DNA units, stacked in a non-classic intercalation site formed by six bases. Sanguinarine interacts with d(CGTACG)2 DNA in its iminium form.

Graphical abstract: X-Ray diffraction analyses of the natural isoquinoline alkaloids Berberine and Sanguinarine complexed with double helix DNA d(CGTACG)

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Article information

DOI
https://doi.org/10.1039/C1CC10971E
Article type
Communication
Submitted
18 Feb 2011
Accepted
04 Mar 2011
First published
22 Mar 2011

Chem. Commun., 2011,47, 4917-4919

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X-Ray diffraction analyses of the natural isoquinoline alkaloids Berberine and Sanguinarine complexed with double helix DNA d(CGTACG)

M. Ferraroni, C. Bazzicalupi, A. R. Bilia and P. Gratteri, Chem. Commun., 2011, 47, 4917 DOI: 10.1039/C1CC10971E

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