Issue 18, 2011

First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase

Abstract

Nerve agents are highly toxic organophosphorus compounds with strong inhibition potency against acetylcholinesterase (AChE). Herein, we describe two first extremely promising uncharged reactivators for poisoned human AChE with a superior or similar in vitro ability to reactivate the enzyme as compared to that of HI-6, obidoxime, TMB-4 and HLö-7.

Graphical abstract: First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase

Supplementary files

Article information

Article type
Communication
Submitted
10 Feb 2011
Accepted
15 Mar 2011
First published
31 Mar 2011

Chem. Commun., 2011,47, 5295-5297

First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase

G. Mercey, T. Verdelet, G. Saint-André, E. Gillon, A. Wagner, R. Baati, L. Jean, F. Nachon and P. Renard, Chem. Commun., 2011, 47, 5295 DOI: 10.1039/C1CC10787A

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