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Issue 20, 2011
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Caged molecular beacons: controlling nucleic acid hybridization with light

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Abstract

We have constructed a novel class of light-activatable caged molecular beacons (cMBs) that are caged by locking two stems with a photo-labile biomolecular interaction or covalent bond. With the cMBs, the nucleic acid hybridization process can be easily controlled with light, which offers the possibility for a high spatiotemporal resolution study of intracellular mRNAs.

Graphical abstract: Caged molecular beacons: controlling nucleic acid hybridization with light

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Publication details

The article was received on 24 Jan 2011, accepted on 04 Apr 2011 and first published on 18 Apr 2011


Article type: Communication
DOI: 10.1039/C1CC10481K
Citation: Chem. Commun., 2011,47, 5708-5710
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    Caged molecular beacons: controlling nucleic acid hybridization with light

    C. Wang, Z. Zhu, Y. Song, H. Lin, C. J. Yang and W. Tan, Chem. Commun., 2011, 47, 5708
    DOI: 10.1039/C1CC10481K

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