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Issue 29, 2011
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Human Carbonic Anhydrase II as a host for piano-stool complexes bearing a sulfonamide anchor

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Abstract

d6-piano-stool complexes bearing an arylsulfonamide anchor display sub-micromolar affinity towards human Carbonic Anhydrase II (hCA II). The 1.3 Å resolution X-ray crystal structure of [(η6-C6Me6)Ru(bispy 3)Cl]+ ⊂ hCA II highlights the nature of the host–guest interactions.

Graphical abstract: Human Carbonic Anhydrase II as a host for piano-stool complexes bearing a sulfonamide anchor

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Publication details

The article was received on 18 Jan 2011, accepted on 08 Jun 2011 and first published on 27 Jun 2011


Article type: Communication
DOI: 10.1039/C1CC10345H
Citation: Chem. Commun., 2011,47, 8238-8240
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    Human Carbonic Anhydrase II as a host for piano-stool complexes bearing a sulfonamide anchor

    F. W. Monnard, T. Heinisch, E. S. Nogueira, T. Schirmer and T. R. Ward, Chem. Commun., 2011, 47, 8238
    DOI: 10.1039/C1CC10345H

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