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Issue 17, 2011
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A smart magnetic resonance imaging contrast agent responsive to adenosine based on a DNA aptamer-conjugated gadolinium complex

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Abstract

We report a general strategy for developing a smart MRI contrast agent for the sensing of small molecules such as adenosine based on a DNA aptamer that is conjugated to a Gd compound and a protein streptavidin. The binding of adenosine to its aptamer results in the dissociation of the Gd compound from the large protein, leading to decreases in the rotational correlation time and thus change of MRI contrast.

Graphical abstract: A smart magnetic resonance imaging contrast agent responsive to adenosine based on a DNA aptamer-conjugated gadolinium complex

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Publication details

The article was received on 09 Jan 2011, accepted on 03 Mar 2011 and first published on 22 Mar 2011


Article type: Communication
DOI: 10.1039/C1CC10161G
Citation: Chem. Commun., 2011,47, 4998-5000
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    A smart magnetic resonance imaging contrast agent responsive to adenosine based on a DNA aptamer-conjugated gadolinium complex

    W. Xu and Y. Lu, Chem. Commun., 2011, 47, 4998
    DOI: 10.1039/C1CC10161G

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