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Issue 18, 2011
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Inhibitors of an essential mycobacterial cell wall lipase (Rv3802c) as tuberculosis drug leads

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Abstract

The first targeted inhibitors of an essential M. tuberculosis cell wall lipase, Rv3802c, are described. Lead compounds exhibited nanomolar inhibition of the enzyme, and encouraging antibacterial activity against M. tuberculosis in vitro, supporting Rv3802c as a novel TB drug target.

Graphical abstract: Inhibitors of an essential mycobacterial cell wall lipase (Rv3802c) as tuberculosis drug leads

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Publication details

The article was received on 16 Dec 2010, accepted on 17 Feb 2011 and first published on 07 Mar 2011


Article type: Communication
DOI: 10.1039/C0CC05635A
Citation: Chem. Commun., 2011,47, 5166-5168
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    Inhibitors of an essential mycobacterial cell wall lipase (Rv3802c) as tuberculosis drug leads

    N. P. West, K. M. Cergol, M. Xue, E. J. Randall, W. J. Britton and R. J. Payne, Chem. Commun., 2011, 47, 5166
    DOI: 10.1039/C0CC05635A

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