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Issue 11, 2011
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Rationally designed fluorescence ‘turn-on’ sensor for Cu2+

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A rationally designed, coumarin-based fluorescent sensor imino-coumarin (IC) displays high selectivity for Cu2+ over a variety of competing metal ions in aqueous solution with a significant fluorescence increase. DFT/TDDFT calculations support that the fluorescence ‘turn-on’ of IC originates from blocking the electron transfer of the nitrogen lone pair upon complexation with Cu2+. IC was successfully applied to microscopic imaging for detection of Cu2+ in LLC-MK2 cells (in vitro) and several living organs (in vivo).

Graphical abstract: Rationally designed fluorescence ‘turn-on’ sensor for Cu2+

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The article was received on 07 Dec 2010, accepted on 06 Jan 2011 and first published on 31 Jan 2011

Article type: Communication
DOI: 10.1039/C0CC05421F
Citation: Chem. Commun., 2011,47, 3165-3167
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    Rationally designed fluorescence ‘turn-on’ sensor for Cu2+

    K. C. Ko, J. Wu, H. J. Kim, P. S. Kwon, J. W. Kim, R. A. Bartsch, J. Y. Lee and J. S. Kim, Chem. Commun., 2011, 47, 3165
    DOI: 10.1039/C0CC05421F

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