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Planar triazinium cations from VO2+-assisted ring cyclizations: a remarkably efficient thiazole species for nuclear staining, PDT and anaerobic photocleavage of DNA
Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore 560012, India
E-mail: arc@ipc.iisc.ernet.in
; Fax: +91 80-23600683
; Tel: +91 80-22932533
b
Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore 560012, India
Chem. Commun., 2011,47, 3954-3956
DOI:
10.1039/C0CC05386D
Received
06 Dec 2010,
Accepted
03 Feb 2011
First published online
21 Feb 2011
Planar triazinium cationic species, from VO2+-assisted cyclization of 1-(2-thiazolylazo)-2-naphthol, shows efficient DNA intercalative binding, visible light-induced anaerobic plasmidDNA photocleavage activity and photocytotoxicity in HeLa and MCF-7 cancer cells by an apoptotic pathway with selective localization of the compound in the nucleus as evidenced from the nuclear staining and confocal imaging.
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