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Issue 13, 2011
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Planar triazinium cations from VO2+-assisted ring cyclizations: a remarkably efficient thiazole species for nuclear staining, PDT and anaerobic photocleavage of DNA

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Abstract

Planar triazinium cationic species, from VO2+-assisted cyclization of 1-(2-thiazolylazo)-2-naphthol, shows efficient DNA intercalative binding, visible light-induced anaerobic plasmid DNA photocleavage activity and photocytotoxicity in HeLa and MCF-7 cancer cells by an apoptotic pathway with selective localization of the compound in the nucleus as evidenced from the nuclear staining and confocal imaging.

Graphical abstract: Planar triazinium cations from VO2+-assisted ring cyclizations: a remarkably efficient thiazole species for nuclear staining, PDT and anaerobic photocleavage of DNA

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Publication details

The article was received on 06 Dec 2010, accepted on 03 Feb 2011 and first published on 21 Feb 2011


Article type: Communication
DOI: 10.1039/C0CC05386D
Citation: Chem. Commun., 2011,47, 3954-3956
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    Planar triazinium cations from VO2+-assisted ring cyclizations: a remarkably efficient thiazole species for nuclear staining, PDT and anaerobic photocleavage of DNA

    P. Prasad, I. Khan, P. K. Sasmal, D. Koley, P. Kondaiah and A. R. Chakravarty, Chem. Commun., 2011, 47, 3954
    DOI: 10.1039/C0CC05386D

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