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Issue 12, 2011
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In vivo trapping of polyketide intermediates from an assembly line synthase using malonyl carba(dethia)-N-acetyl cysteamines

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Abstract

Early-stage intermediates in the biosynthesis of erythromycin A by Saccharopolyspora erythraea were intercepted by malonyl carba(dethia)-N-acetyl cysteamines, generated in vivo from the hydrolysis of the corresponding methyl esters.

Graphical abstract: In vivo trapping of polyketide intermediates from an assembly line synthase using malonyl carba(dethia)-N-acetyl cysteamines

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Publication details

The article was received on 21 Nov 2010, accepted on 24 Jan 2011 and first published on 08 Feb 2011


Article type: Communication
DOI: 10.1039/C0CC05077F
Citation: Chem. Commun., 2011,47, 3460-3462
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    In vivo trapping of polyketide intermediates from an assembly line synthase using malonyl carba(dethia)-N-acetyl cysteamines

    M. Tosin, Y. Demydchuk, J. S. Parascandolo, C. Blasco Per, F. J. Leeper and P. F. Leadlay, Chem. Commun., 2011, 47, 3460
    DOI: 10.1039/C0CC05077F

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