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Issue 6, 2011
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Palladium-mediated site-selective Suzuki–Miyaura protein modification at genetically encoded aryl halides

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Abstract

Site-specific genetic incorporation of unnatural p-halophenylalanine amino acid residues as ‘tags’ coupled with Pd(0)-mediated Suzuki–Miyuara ‘modification’ has been enabled by discovery of an effective small molecule palladium scavenger.

Graphical abstract: Palladium-mediated site-selective Suzuki–Miyaura protein modification at genetically encoded aryl halides

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Publication details

The article was received on 15 Nov 2010, accepted on 08 Dec 2010 and first published on 04 Jan 2011


Article type: Communication
DOI: 10.1039/C0CC04970K
Citation: Chem. Commun., 2011,47, 1698-1700
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    Palladium-mediated site-selective Suzuki–Miyaura protein modification at genetically encoded aryl halides

    C. D. Spicer and B. G. Davis, Chem. Commun., 2011, 47, 1698
    DOI: 10.1039/C0CC04970K

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