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Issue 9, 2011
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A natural product-like inhibitor of NEDD8-activating enzyme

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Abstract

The natural product-like 6,6″-biapigenin has been identified as only the second inhibitor of NEDD8-activating enzyme using virtual screening. This compound was active in enzyme and cell-based assays, with potency in the micromolar range.

Graphical abstract: A natural product-like inhibitor of NEDD8-activating enzyme

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Publication details

The article was received on 12 Nov 2010, accepted on 15 Dec 2010 and first published on 14 Jan 2011


Article type: Communication
DOI: 10.1039/C0CC04927A
Citation: Chem. Commun., 2011,47, 2511-2513
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    A natural product-like inhibitor of NEDD8-activating enzyme

    C. Leung, D. S. Chan, H. Yang, R. Abagyan, S. M. Lee, G. Zhu, W. Fong and D. Ma, Chem. Commun., 2011, 47, 2511
    DOI: 10.1039/C0CC04927A

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