Issue 8, 2011
From the journal:

Chemical Communications

Single-step kinase inhibitor screening using a peptide-modified gold nanoparticle platform†

Shalini Gupta,a   Heiko Andresena  and  Molly M. Stevens*a  

* Corresponding authors

a Imperial College London, Department of Materials and Institute for Biomedical Engineering, Department of Bioengineering, Prince Consort Road, London, UK
E-mail: m.stevens@imperial.ac.uk
Fax: +44 (0)207 594 6757
Tel: +44 (0)207 594 6804

Abstract

Two complementary formats for kinase inhibitor screening are presented in which peptide-modified gold nanoparticles are enzymatically phosphorylated and rapidly aggregate on a surface or in solution by action of phosphospecific antibodies. The simple and rapid colourimetric response of the assays makes them an attractive approach for drug-screening applications.

Graphical abstract: Single-step kinase inhibitor screening using a peptide-modified gold nanoparticle platform

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Article information

DOI
https://doi.org/10.1039/C0CC04903D
Article type
Communication
Submitted
11 Nov 2010
Accepted
21 Dec 2010
First published
18 Jan 2011

Chem. Commun., 2011,47, 2249-2251

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Single-step kinase inhibitor screening using a peptide-modified gold nanoparticle platform

S. Gupta, H. Andresen and M. M. Stevens, Chem. Commun., 2011, 47, 2249 DOI: 10.1039/C0CC04903D

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