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Issue 13, 2011
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Single-walled carbon nanotubes chemiresistor aptasensors for small molecules: picomolar level detection of adenosine triphosphate

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Abstract

Here we report single walled-carbon nanotubes (SWNTs)-based chemiresistor aptasensors for highly sensitive and selective detection of weakly or uncharged molecules using the displacement format. As a proof-of-concept we demonstrate the detection of ATP, a small weakly charged molecule, by displacement of the ssDNA anti-ATP aptamer hybridized to a small capture oligonucleotide covalently attached on SWNTs, with picomolar sensitivity and selectivity over GTP.

Graphical abstract: Single-walled carbon nanotubes chemiresistor aptasensors for small molecules: picomolar level detection of adenosine triphosphate

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Publication details

The article was received on 01 Nov 2010, accepted on 14 Jan 2011 and first published on 02 Feb 2011


Article type: Communication
DOI: 10.1039/C0CC04733C
Citation: Chem. Commun., 2011,47, 3793-3795
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    Single-walled carbon nanotubes chemiresistor aptasensors for small molecules: picomolar level detection of adenosine triphosphate

    B. K. Das, C. Tlili, S. Badhulika, L. N. Cella, W. Chen and A. Mulchandani, Chem. Commun., 2011, 47, 3793
    DOI: 10.1039/C0CC04733C

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