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Issue 5, 2011
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Bead diffusion assay for discovering antimicrobial cyclic peptides

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Abstract

A combinatorial library of 15 536 cyclic decapeptide analogues of tyrocidine A and gramicidin S was prepared on photocleavable TentaGel beads. The beads were photolyzed without solvent, and spread onto an agar plate inoculated with bacterial lawn. Clear zones were formed around beads carrying antimicrobially active peptides such as E18 c(kVOrnLfThiYOrnLq), which inhibited growth of B. subtilis and selected MRSA strains.

Graphical abstract: Bead diffusion assay for discovering antimicrobial cyclic peptides

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Publication details

The article was received on 28 Oct 2010, accepted on 22 Nov 2010 and first published on 10 Dec 2010


Article type: Communication
DOI: 10.1039/C0CC04670A
Citation: Chem. Commun., 2011,47, 1434-1436
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    Bead diffusion assay for discovering antimicrobial cyclic peptides

    V. S. Fluxà, N. Maillard, M. G. P. Page and J. Reymond, Chem. Commun., 2011, 47, 1434
    DOI: 10.1039/C0CC04670A

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