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Issue 11, 2011
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Functionalisation of aldehydesvia aerobic hydroacylation of azodicarboxylates ‘on’ water

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Abstract

Herein we report the functionalisation of aldehydesvia hydroacylation of azodicarboxylates. A range of functionalised aldehydes are employed as the limiting reagent including chiral non-racemic aldehydes bearing α-stereocentres which are functionalised giving access to enantiomerically pure products. The resultant hydrazides can be employed as acyl donors in the synthesis of amides.

Graphical abstract: Functionalisation of aldehydesvia aerobic hydroacylation of azodicarboxylates ‘on’ water

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Publication details

The article was received on 20 Oct 2010, accepted on 21 Dec 2010 and first published on 01 Feb 2011


Article type: Communication
DOI: 10.1039/C0CC04520A
Citation: Chem. Commun., 2011,47, 3269-3271
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    Functionalisation of aldehydesvia aerobic hydroacylation of azodicarboxylates ‘on’ water

    V. Chudasama, J. M. Ahern, D. V. Dhokia, R. J. Fitzmaurice and S. Caddick, Chem. Commun., 2011, 47, 3269
    DOI: 10.1039/C0CC04520A

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